The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein.

@article{Blanco2001TheK,
  title={The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein.},
  author={Gonzalo Blanco and Gary R. Coulton and Andrew Biggin and Christopher Grainge and Joel Moss and Michael Barrett and Anne D Berquin and G. Marechal and Michael J Skynner and P van Mier and A Nikitopoulou and Michaela Kraus and Chris Paul Ponting and Roger M. Mason and Steve D. M. Brown},
  journal={Human molecular genetics},
  year={2001},
  volume={10 1},
  pages={9-16}
}
The ky mouse mutant exhibits a primary degenerative myopathy preceding chronic thoraco-lumbar kyphoscoliosis. The histopathology of the ky mutant suggests that Ky protein activity is crucial for normal muscle growth and function as well as the maturation and stabilization of the neuromuscular junction. Muscle hypertrophy in response to increasing demand is deficient in the ky mutant, whereas adaptive fibre type shifts take place. The ky locus has previously been localized to a small region of… CONTINUE READING

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