The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations
@article{Tan2012TheKP, title={The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations}, author={Lin Tan and Jin-Tai Yu and Lan Tan}, journal={Journal of the Neurological Sciences}, year={2012}, volume={323}, pages={1-8} }
107 Citations
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
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This review focused on the KP metabolites through the relationship of neuroinflammation in AD, significant KP metabolites, and associated molecular mechanisms as well as the utility of these metabolites as biomarkers and therapeutic targets for patients with AD.
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This review highlights the alterations in this metabolic pathway in the physiological aging process and in different disorders, which can be achieved through the use of synthetic kynurenic acid analogues, enzyme inhibitors or even nanotechnology.
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The purpose of this review is to describe the kynurenine pathway, the klynurenine 3-monooxygenase enzyme, and KMO inhibitors and their potential candidacy for clinical use.
The Kynurenine Pathway in Stem Cell Biology
- BiologyInternational journal of tryptophan research : IJTR
- 2013
Evidence showing that the kynurenine pathway influences stem cell biology and impacts the functional behavior of progenitor cells is considered.
The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum
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- 2014
Neuronal proteins as targets of 3-hydroxykynurenine: Implications in neurodegenerative diseases.
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- 2019
The results open the perspective to using the 3OHKyn-protein/peptide synthetic conjugates to explore their competence to activate microglia cell cultures as well as to unravel their role in neuroinflammatory conditions.
Role of the Kynurenine Pathway in Stem Cell Biology
- Biology
- 2015
This chapter considers the current understanding of the role of the KP in stem cell biology and impacts on the functional behaviour of progenitor cells.
Antioxidant Properties of Kynurenines: Density Functional Theory Calculations
- ChemistryPLoS Comput. Biol.
- 2016
The high free radical scavenging activity of 3HAA and 3HOK can be explained by the easiness of H-atom abstraction and transfer to O-atom of the free radical, rather than by Met-OO* addition to the kynurenine radical.
References
SHOWING 1-10 OF 80 REFERENCES
Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.
- Biology, PsychologyJournal of neural transmission. Supplementum
- 2006
It seems hopeful to use kynurenine derivatives or enzyme inhibitors to ensure an increased kynurenic acid concentration in the central nervous system to exert its neuroprotective effects binding at the excitatory glutamate receptors, in particular the NMDA receptors.
Kynurenine and its metabolites in Alzheimer's disease patients.
- Biology, ChemistryAdvances in medical sciences
- 2010
Examination of peripheral KP in patients with Alzheimer type dementia proves activation of peripheral kynurenine pathway in this type of dementia and offers Novel therapeutic opportunities, with the development of new compounds as a promising perspective for brain neuroprotection.
Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease.
- Biology, ChemistryMedical hypotheses
- 2011
Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease.
- BiologyCNS & neurological disorders drug targets
- 2010
The enzyme kynurenine 3-monooxygenase (KMO) is located at a critical branching point in the KP such that inhibition of this enzyme by either pharmacological or genetic means shifts the flux in the pathway towards the formation of KYNA.
Implications for the Kynurenine Pathway and Quinolinic Acid in Amyotrophic Lateral Sclerosis
- BiologyNeurodegenerative Diseases
- 2005
The kynurenine pathway is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules and most of the factors associated with QUIN toxicity are found in ALS, implying that QUIN may play a substantial role in the neuropathogenesis of ALS.
The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease
- BiologyCurrent Biology
- 2011
Targeting the kynurenine pathway-related alterations in Alzheimer's disease: a future therapeutic strategy.
- BiologyJournal of Alzheimer's disease : JAD
- 2011
There is a great need for new strategies to improve efficacy, transport across the blood-brain barrier and bioavailability, naturally with simultaneous minimization of the adverse side-effects.
The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection
- Biology, ChemistryJournal of the Neurological Sciences
- 2009
The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
- Biology, PsychologyParkinson's disease
- 2011
It is likely that pharmacological modulation of the KP will represent a new therapeutic strategy for PD, and previous studies have shown that NMDA antagonists can ease symptoms and exert a neuroprotective effect in PD both in vivo and in vitro.