The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

@article{Marx2020TheKP,
  title={The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies},
  author={Wolfgang Marx and Amelia J McGuinness and Tetyana Rocks and Anu Ruusunen and Jasmine Cleminson and Adam J. Walker and Susana Gomes-da-Costa and Melissa M Lane and Marsal Sanches and Alexandre Paim Diaz and Ping-Tao Tseng and Pao-Yen Lin and Michael Berk and Gerard Clarke and Adrienne O'Neil and Felice N. Jacka and Brendon Stubbs and Andr{\'e} Ferrer Carvalho and Jo{\~a}o Quevedo and Jair C. Soares and Brisa S. Fernandes},
  journal={Molecular Psychiatry},
  year={2020},
  pages={1 - 21}
}
The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the differences in kynurenine metabolites in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). Electronic databases were searched for studies that assessed metabolites involved in the kynurenine… Expand

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