The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites

  title={The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites},
  author={Francesco Bartoli and Błażej Misiak and Tommaso Callovini and Daniele Cavaleri and Riccardo M. Cioni and Cristina Crocamo and Jonathan B. Savitz and Giuseppe Carr{\`a}},
  journal={Molecular Psychiatry},
Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the possible differences in peripheral blood levels of KP metabolites between individuals with BD and healthy controls. We searched Medline, Embase, and PsycInfo electronic databases for articles indexed up to February 2020. We included any observational study comparing the peripheral blood levels of at least one KP metabolite… Expand

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