The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites

@article{Bartoli2020TheKP,
  title={The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites},
  author={Francesco Bartoli and Błażej Misiak and Tommaso Callovini and Daniele Cavaleri and Riccardo M. Cioni and Cristina Crocamo and Jonathan B. Savitz and Giuseppe Carr{\`a}},
  journal={Molecular Psychiatry},
  year={2020},
  volume={26},
  pages={3419-3429}
}
Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the possible differences in peripheral blood levels of KP metabolites between individuals with BD and healthy controls. We searched Medline, Embase, and PsycInfo electronic databases for articles indexed up to February 2020. We included any observational study comparing the peripheral blood levels of at least one KP metabolite… 

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References

SHOWING 1-10 OF 84 REFERENCES

Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis

TLDR
Overall, KYNA levels are increased in patients with schizophrenia, specifically within the central nervous system, and an improved understanding of KYNA in Patients with schizophrenia may contribute to the development of novel diagnostic approaches and therapeutic strategies.

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls

TLDR
These findings implicate brain-specific regulation of KYNA under physiological as well as under pathophysiological conditions and strengthen the previous observation of CSF KYNA as a biomarker in BD.

Kynurenine pathway in depression: A systematic review and meta-analysis

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder

TLDR
This study provides a new diagnostic method to study MDD based on plasma KYNA level, and suggests that KYNA would be a potential biomarker in diagnosing depression patients.

Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders

TLDR
The present results suggest the kynurenine pathway of tryptophan metabolism, noradrenergic and purinergic system dysfunction as trait factors in schizophrenia spectrum and bipolar disorders.

The HPA axis in bipolar disorder: Systematic review and meta-analysis

Tryptophan and Kynurenine Metabolites: Are They Related to Depression?

TLDR
Findings are opposite to expectations and not consistent with a hypothesized increased conversion from TRY to KYN in depressed subjects, and there is no evidence of altered production of serotonin as 5-HIAA concentration was unchanged.

Meta-analysis of Cerebrospinal Fluid Cytokine and Tryptophan Catabolite Alterations in Psychiatric Patients: Comparisons Between Schizophrenia, Bipolar Disorder, and Depression

TLDR
There is preliminary evidence for similarities in the pattern of CSF cytokine and tryptophan catabolite alterations across major psychiatric disorders, although findings must be interpreted with caution in light of small numbers of studies/subjects.

Tryptophan breakdown pathway in bipolar mania.

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