The kynurenine load test, an adjunct to the tryptophan load test.


The kynurenine load test was introduced to distinguish, in vivo, between abnormal tryptophan metabolism caused by induction of tryptophan oxygenase or by impaired kynureninase function. This test was carried out by giving a loading dose of 700 mumol L-kynurenine sulphate followed by determination of urinary metabolites of the tryptophan-nicotinic acid… (More)