The kynurenic acid hypothesis of schizophrenia.

  title={The kynurenic acid hypothesis of schizophrenia.},
  author={S Erhardt and Lilly Schwieler and Linda K Nilsson and Klas R. Linderholm and G{\"o}ran Engberg},
  journal={Physiology & behavior},
  volume={92 1-2},
In recent years progress in the field of schizophrenia research has led to the suggestion that dopamine only plays an intermediary role in the pathophysiology of the disease and that the main abnormalities lie elsewhere. In particular, deficits in brain glutamatergic systems are suggested to play a prominent role in the pathophysiology of the disease. Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl-D-aspartate-receptor… CONTINUE READING
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