The knowledge system underpinning healthcare is not fit for purpose and must change

@article{Roberts2015TheKS,
  title={The knowledge system underpinning healthcare is not fit for purpose and must change},
  author={Ian Roberts and Katharine Ker and Phil Edwards and Deirdre Beecher and Daniela Manno and E. A. Sydenham},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={350}
}
The medical literature is biased and inundated with poor quality trials. Ian Roberts and colleagues explain how these problems affect systematic reviews and how they might be overcome 
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Patients are receiving treatment that may be unsound as investigations by Ian Roberts and colleagues raise questions about whether influential trials of high dose mannitol ever took place
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TLDR
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TLDR
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