The knockdown of c-myc expression by RNAi inhibits cell proliferation in human colon cancer HT-29 cells in vitro and in vivo

@article{Zhang2009TheKO,
  title={The knockdown of c-myc expression by RNAi inhibits cell proliferation in human colon cancer HT-29 cells in vitro and in vivo},
  author={Xiao Zhang and Yin-lin Ge and Run-hua Tian},
  journal={Cellular & Molecular Biology Letters},
  year={2009},
  volume={14},
  pages={305-318}
}
We investigated the effects of RNA interference-mediated silencing of the c-myc gene on celluar proliferation and apoptosis in human colon cancer HT-29 cells in vitro and in vivo. A small interfering RNA (siRNA) targeting c-myc was designed, the DNA template was synthesized, and the siRNA was obtained by in vitro transcription. After siRNA transfection into… CONTINUE READING