The kleisin subunit of cohesin dictates damage-induced cohesion.

Abstract

Cohesin, the protein complex that mediates sister chromatid cohesion, is required for faithful chromosome segregation and efficient repair of double-strand breaks (DSBs). Cohesion generation is normally restricted to S phase. However, in G2/M, a DSB activates cohesion generation near the DSB and genome-wide. Here, using budding yeast, we show that DSB… (More)
DOI: 10.1016/j.molcel.2008.06.005

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