The kinetochore and the centromere: a working long distance relationship.

  title={The kinetochore and the centromere: a working long distance relationship.},
  author={Marcin R Przewloka and David M Glover},
  journal={Annual review of genetics},
Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Consequently, elaborate molecular machineries and mechanisms emerged during the course of evolution in order to ensure proper division of the genetic material. The kinetochore, an essential multiprotein complex assembled on mitotic or meiotic centromeres, is an example of such machinery. Recently considerable progress has been made in understanding their composition, the recruitment hierarchy of… CONTINUE READING
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