The kinetics of triclabendazole disposition in sheep.

  title={The kinetics of triclabendazole disposition in sheep.},
  author={D. R. Hennessy and Ernest Lacey and J. W. Steel and Roger Prichard},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={10 1},
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheep surgically fitted with a permanent re-entrant bile duct cannula. The profiles of TCBZ metabolites in peripheral plasma and bile were determined using high performance liquid chromatography. In plasma, only TCBZ sulphoxide (TCBZ-SO) and TCBZ sulphone were present and reached their maximum… 
Biliary secretion and enterohepatic recycling of fenbendazole metabolites in sheep.
It is suggested that during the process of recycling-biliary metabolites make substantial contact with parasites in the mucosa of the small and large intestine thereby contributing to the anti-helminthic activity of FBZ.
Pharmacokinetics and efficacy of triclabendazole in goats with induced fascioliasis
The pharmacokinetic behaviour of triclabendazole was not altered in animals with fascioliasis and the drug against immature (six-week) F. hepatica was 100%.
Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica
Unlike the uptake pattern previously observed for albendazole, the parent TCBZ and its sulphoxide and sulphone metabolites showed a similar ability to penetrate into the trematode parasite.
An altered influx/efflux mechanism may account for the development of resistance to TCBZ in F. hepatica.
Effect of food on the bioavailability of triclabendazole in patients with fascioliasis.
The administration of triclabendazole with food is recommended for improved systemic availability in patients with fascioliasis or paragonimiasis and a large availability increase with food and the strong systemic predominance of the active sulphoxide metabolite over the unchanged drug.
The disposition of albendazole in sheep.
Albendazole (ABZ) was administered intraruminally to sheep fitted with a permanent bile-duct cannula to determine if its metabolites might contribute to its flukicidal action and it is suggested that ABZ is sequestered in the liver.
Efficacy against Fasciola hepatica and the pharmacokinetics of triclabendazole administered by oral and topical routes.
TCBZ administered orally at 12 mg/kg resulted in greater efficacy against 28-day-old, early immature liver fluke than was achieved by topical administration at 30mg/kg, and plasma metabolites of TCBZ were higher and liver pathology was less in TOS-treated animals than in TA- treated animals.
Effect of Fascioliasis on the pharmacokinetic parameters of triclabendazole in human subjects
Fasioliasis as an infective condition widely spread in Egypt has no significant effect on the pharmacokinetic parameters of the orally administered TCBZ and at the same time it is very effective against the parasite which strongly and safely suggests the use of this medication for the treatment of this infection.


Pharmacokinetics of fenbendazole in sheep.
Plasma concentrations of fenbendazole were less and persisted for a shorter period after intra-abomasal administration than after oral administration, and much of the anthelmintic activity ofFenbENDazole may be due to the oxfendazoles metabolite.
Pharmacokinetics of albendazole in sheep.
It is probable that much of the anthelmintic activity of albendazole in sheep is due to the metabolically formed sulfoxide and sulfone.
Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole
A new benzimidazole anthelmintic, triclabendazole (CGA-89317) was found to be highly efficient against mature and early immature Fasciola hepatica infections in sheep. At the dose rate of 2.5 mg/kg
The metabolism of xenobiotic compounds by Hymenolepis diminuta (Cestoda: Cyclophyllidea).
The phase I detoxification systems of H. diminuta differ considerably from those of its rat host; the results suggest that, within the cestodes, there may be considerable species variation in detoxification reactions.
Effect of increasing intakes of Zn, Cu, and Mn on their secretion via bile and pancreatic juice and their excretion in faeces and urine in sheep fed lucerne pellets.
The high intake of microelements (the available evidence suggests the Zn) damaged the exocrine cells of the pancreas and also signified damage to the liver and kidney.
Fenbendazole. II. Biological properties and activity
Fenbendazole has a broad spectrum of activity against immature and adult helminths of the intestinal tract and lungs at an oral dose of 5–7.5 mg/kg. This compound has a wide margin of safety in
Methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate, a new, potent anthelmintic.
This work confirmed the previous suggestion that the Wenger assay system determines exclusively the activity of lactosylceramidase I, which is probably identical with galactoylceramide beta-galactosidase.
Nitrations of acetanilides by reagents of NO2X type
The distribution of products in the nitration of a series of eight substituted acetanilides has been studied using differing nitrating agents.With mixed nitric and sulfuric acids, attack para to the