The kinetics of triclabendazole disposition in sheep.

@article{Hennessy1987TheKO,
  title={The kinetics of triclabendazole disposition in sheep.},
  author={D. R. Hennessy and Ernest Lacey and J. W. Steel and Roger Prichard},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1987},
  volume={10 1},
  pages={
          64-72
        }
}
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheep surgically fitted with a permanent re-entrant bile duct cannula. The profiles of TCBZ metabolites in peripheral plasma and bile were determined using high performance liquid chromatography. In plasma, only TCBZ sulphoxide (TCBZ-SO) and TCBZ sulphone were present and reached their maximum… 
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Albendazole (ABZ) was administered intraruminally to sheep fitted with a permanent bile-duct cannula to determine if its metabolites might contribute to its flukicidal action and it is suggested that ABZ is sequestered in the liver.
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TLDR
TCBZ administered orally at 12 mg/kg resulted in greater efficacy against 28-day-old, early immature liver fluke than was achieved by topical administration at 30mg/kg, and plasma metabolites of TCBZ were higher and liver pathology was less in TOS-treated animals than in TA- treated animals.
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TLDR
Fasioliasis as an infective condition widely spread in Egypt has no significant effect on the pharmacokinetic parameters of the orally administered TCBZ and at the same time it is very effective against the parasite which strongly and safely suggests the use of this medication for the treatment of this infection.
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