The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes.

@article{Iacopetta1983TheKO,
  title={The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes.},
  author={Barry J. Iacopetta and E. J. H. Morgan},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 15},
  pages={
          9108-15
        }
}
The endocytosis of diferric transferrin and accumulation of its iron by freshly isolated rabbit reticulocytes was studied using 59Fe-125I-transferrin. Internalized transferrin was distinguished from surface-bound transferrin by its resistance to release during treatment with Pronase at 4 degrees C. Endocytosis of diferric transferrin occurs at the same rate as exocytosis of apotransferrin, the rate constants being 0.08 min-1 at 22 degrees C, 0.19 min-1 at 30 degrees C, and 0.45 min-1 at 37… CONTINUE READING

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