Corpus ID: 5868643

The kinetics of tiazofurin uptake by the isolated perfused choroid plexus of the sheep.

@article{Redzic2000TheKO,
  title={The kinetics of tiazofurin uptake by the isolated perfused choroid plexus of the sheep.},
  author={Zoran B. Redzic and Malcolm B. Segal and Jovana M Ga{\vs}i{\'c} and Ivanka Markovic and Aleksandra J. Isakovic and Ljubisav Raki{\'c}},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2000},
  volume={22 3},
  pages={
          149-54
        }
}
  • Z. Redzic, M. Segal, +3 authors L. Rakić
  • Published 1 April 2000
  • Chemistry, Medicine
  • Methods and findings in experimental and clinical pharmacology
Tiazofurin (TZF-beta-D-ribofuronosyl thiazole-4-carboxamide, NSC-286193) is a synthetic nucleoside analog with potent antitumor activity. Isolated choroid plexuses (CP) of sheep were perfused in situ and the uptake of [3H]-tiazofurin was determined in relation to the recovery of [14C]-mannitol by means of the paired indicator dilution technique. The maximal uptake of tiazofurin was 8.29 +/- 0.84% and was shown to be both carrier-mediated, sodium-dependent and inhibited by adenosine which… Expand
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  • Biology, Medicine
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  • 2001
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