The kinetics of serum hCG and progesterone in response to oral and vaginal administration of misoprostol during medical termination of early pregnancy.

@article{Honkanen2002TheKO,
  title={The kinetics of serum hCG and progesterone in response to oral and vaginal administration of misoprostol during medical termination of early pregnancy.},
  author={Helena Honkanen and Sirpa Ranta and Olavi Ylikorkala and Oskari Heikinheimo},
  journal={Human reproduction},
  year={2002},
  volume={17 9},
  pages={
          2315-9
        }
}
BACKGROUND Misoprostol is widely used in combination with mifepristone for medical termination of pregnancy. We studied the endocrine parameters of trophoblast function during medical termination of early pregnancy using mifepristone in combination with oral or vaginal misoprostol. The effect of prolonged misoprostol administration was also examined. METHODS Thirty-four women, requesting termination of pregnancy and with <or=63 days of amenorrhoea, received 200 mg of mifepristone on day 0… 
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TLDR
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TLDR
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Changes in circulating concentrations of inhibins A and pro-alpha C during first trimester medical termination of pregnancy.
TLDR
Treatment with mifepristone, a competitive antagonist of the progesterone receptor, resulted in a significant and rapid fall in concentrations of inhibin pro-alpha C, identifying a link between production of pro- alpha C and luteal steroidogenesis in early human pregnancy.
Prostaglandins for first-trimester termination.
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