The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma

@article{Lutz1975TheKO,
  title={The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma},
  author={Robert J. Lutz and Robert L. Dedrick and James A. Straw and Michael M. Hart and Philip Klubes and Daniel S. Zaharko},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1975},
  volume={3},
  pages={77-97}
}
A mathematical model is presented to simulate the time-dependent uptake of methotrexate in spontaneous canine lymphosarcomas in vivo.Blood flow rates in these tumors are high so that transport to the tumor is limited by cell membrane resistance. A significant amount of rapidly exchangeable methotrexate appears to exist in extracellular space loosely bound to proteins or cell membranes. Transmembrane drug transport follows Michaelis-Menten kinetics, with the maximum facilitated transport ranging… CONTINUE READING

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