The kinetics of inhibition with methotrexate and vinblastine of the primary immune response to sheep red blood cells in mice.

Forty-eight or 72 h after immunization with sheep red blood cells, CBA mice were injected intraperitoneally with a single dose of methotrexate or vinblastine, 2.5 mg/kg and 1.5 mg/kg respectively, and then the number of direct plaque-forming cells in their spleen was estimated at 4-h intervals. The PFC growth curve showed an exponential and staircase… (More)