The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i

@article{Lyubarsky1996TheKO,
  title={The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i},
  author={Arkady L. Lyubarsky and S F Nikonov and E. N. Pugh},
  journal={The Journal of General Physiology},
  year={1996},
  volume={107},
  pages={19 - 34}
}
A rich variety of mechanisms govern the inactivation of the rod phototransduction cascade. These include rhodopsin phosphorylation and subsequent binding of arrestin; modulation of rhodopsin kinase by S-modulin (recoverin); regulation of G-protein and phosphodiesterase inactivation by GTPase-activating factors; and modulation of guanylyl cyclase by a high-affinity Ca(2+)-binding protein. The dependence of several of the inactivation mechanisms on Ca2+i makes it difficult to assess the… CONTINUE READING

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