The kinetics of electrical activity of beta cells in response to a "square wave" stimulation with glucose or glibenclamide.

@article{Meiner1976TheKO,
  title={The kinetics of electrical activity of beta cells in response to a "square wave" stimulation with glucose or glibenclamide.},
  author={Hans-Georg Mei\ssner and Illani Atwater},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1976},
  volume={8 1},
  pages={11-6}
}
The effect of a "square wave" stimulation with glucose or glibenclamide on the electrical activity of beta-cells has been studied with microelectrode techniques in isolated perifused mouse islets. While glucose evoked a burst activity with periodic oscillations of the membrane potential between two levels, glibenclamide produced a constant depolarization with a continuous spike activity. In both cases the time course of activity was biphasic and resembled closely the corresponding patterns of… CONTINUE READING

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