The kinetics of competitive radioligand binding predicted by the law of mass action.

@article{Motulsky1984TheKO,
  title={The kinetics of competitive radioligand binding predicted by the law of mass action.},
  author={Harvey J. Motulsky and Lawrence C. Mahan},
  journal={Molecular pharmacology},
  year={1984},
  volume={25 1},
  pages={1-9}
}
Although equilibrium competitive radioligand binding studies are often used to characterize hormone and neurotransmitter receptors, the kinetics of such experiments have not been extensively explored. The interactions of the radioligand and competitor with the receptors can be described by two differential equations which can be solved to yield a single equation describing the binding of the radioligand as a function of time. This equation has several applications: First, it can be used to… CONTINUE READING
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