The kinetics and redox state of nitric oxide determine the biological consequences in lung adenocarcinoma.

@article{Bentz2007TheKA,
  title={The kinetics and redox state of nitric oxide determine the biological consequences in lung adenocarcinoma.},
  author={Brandon G. Bentz and Neal D. Hammer and Brett Milash and S. Klein and David M. Burnett and James A. Radosevich and G. Kenneth Haines},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  year={2007},
  volume={28 6},
  pages={301-11}
}
Few studies have explored the mechanistic basis for the apparent paradoxical effects of nitric oxide and its interrelated redox species (NO(X)) in cancer biology. Our aim was to determine the differential effects of the redox state and kinetics of nitrosative species on the key cancer processes of apoptosis. Therefore, a murine lung adenocarcinoma cell line was exposed to various NO(X) donor compounds differing in redox state and delivery kinetics. DNA strand breaks (DSBs) were measured by the… CONTINUE READING