The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres

@article{Noble1968TheKA,
  title={The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres},
  author={Denis Noble and Richard W. Tsien},
  journal={The Journal of Physiology},
  year={1968},
  volume={195}
}
1. The reversal potential of the slow outward current in Purkinje fibres varies with [K]o in accordance with the expected potassium equilibrium potential. It is concluded that virtually all of this current is carried by potassium ions. 
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References

SHOWING 1-10 OF 36 REFERENCES
The time and voltage dependence of the slow outward current in cardiac Purkinje fibres
1. In normal Tyrode solution the initial inward sodium current which is produced in Purkinje fibres in response to a sudden depolarization is followed by a very slow change in current in an outwardExpand
The effect of subthreshold potentials on the membrane current in cardiac Purkinje fibres
1. In sodium‐containing solutions, up to 60% of the slow outward current in Purkinje fibres can be activated by depolarizations which are too small to activate the fast sodium conductance responsibleExpand
Membrane capacity of the cardiac Purkinje fibre
  • H. Fozzard
  • Medicine, Chemistry
  • The Journal of physiology
  • 1966
TLDR
The basis for the relatively high membrane capacitance of the cardiac Purkinje fibre has been investigated and it is shown that the fibre has low barriers to doping and high resistance to high temperatures. Expand
Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride
TLDR
Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. Expand
The effect of the cardiac membrane potential on the rapid availability of the sodium‐carrying system
  • S. Weidmann
  • Chemistry, Medicine
  • The Journal of physiology
  • 1955
TLDR
The present experiments were undertaken in order to look for a similar effect in mammalian Purkinje fibres by means of a feedback circuit the 'resting' potential could be chosen at will; its effect was observed on certain features of the action potential which are thought to be indicative of the sodium permeability, namely the upstroke velocity and the size of the 'overshoot'. Expand
Chloride ions and the membrane potential of Purkinje fibres
  • E. Carmeliet
  • Chemistry, Medicine
  • The Journal of physiology
  • 1961
TLDR
The results suggest that the contribution of chloride ions to the total membrane conductance is low in a resting fibre but increases when a fibre is depolarized. Expand
The effect of temperature on the sodium and potassium permeability changes in myelinated nerve fibres of Xenopus laevis
The purpose of the present investigation was to determine the effects which changes in temperature have on the constants governing the permeability changes in the myelinated nerve fibre. VoltageExpand
A quantitative description of membrane current and its application to conduction and excitation in nerve
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms. Expand
Slow changes of potassium permeability in the squid giant axon.
TLDR
The modified equation is similar in form to the Hodgkin-Huxley equation for sodium current, suggesting that the mechanism for the passive transport of potassium through the axon membrane is similar to that for sodium. Expand
Potassium permeability in myelinated nerve fibres of Xenopus laevis
TLDR
It will be shown that the simple constant-field equation (Goldman 1943; Hodgkin & Katz, 1949; Dodge & Frankenhaeuser, 1959) is applicable to the experimental data, even though some limitations to the treatment were observed. Expand
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