The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids.

@article{Zhang2012TheKA,
  title={The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids.},
  author={Amy Yueming Zhang and Shankar Balasubramanian},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 46},
  pages={
          19297-308
        }
}
The folding kinetics of G-quadruplex forming sequences is critical to their capacity to influence biological function. While G-quadruplex structure and stability have been relatively well studied, little is known about the kinetics of their folding. We employed a stopped-flow mixing technique to systematically investigate the potassium-dependent folding kinetics of telomeric RNA and DNA G-quadruplexes and RNA G-quadruplexes containing only two G-quartets formed from sequences r[(GGA)(3)GG] and… CONTINUE READING
BETA

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies.

  • Biochimica et biophysica acta. General subjects
  • 2017
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations.

  • Nucleic acids research
  • 2015
VIEW 4 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

Folding and unfolding pathways of the human telomeric G-quadruplex.

  • Journal of molecular biology
  • 2014
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Extended molecular dynamics of a c-kit promoter quadruplex

  • Nucleic acids research
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

G-quadruplexes and their regulatory roles in biology

  • Nucleic acids research
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.

Similar Papers