The kinetic parameters of sodium currents in maturing acutely isolated rat hippocampal CA1 neurones.

@article{Costa1996TheKP,
  title={The kinetic parameters of sodium currents in maturing acutely isolated rat hippocampal CA1 neurones.},
  author={Pedro Freire Costa},
  journal={Brain research. Developmental brain research},
  year={1996},
  volume={91 1},
  pages={29-40}
}
Whole-cell voltage clamp techniques were used to characterize the kinetics of INa in immature (P3-5) and older (P > 25) acutely isolated rat CA1 hippocampal neurones. Fast-rising and fast-inactivating currents were recorded at all stages of maturation, evocable from Vm values of -55 to -50 mV. Currents were sensitive to TTX (1 microM) and to sodium removal from the perfusate. Current density and maximum slope conductance increased with maturation. Current decay was described by two exponentials… CONTINUE READING

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