The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a specialized enzyme for the elimination of high superoxide concentrations.

@article{Abreu2008TheKM,
  title={The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a specialized enzyme for the elimination of high superoxide concentrations.},
  author={Isabel A. Abreu and Amy S Hearn and Haiqain An and Harry S. Nick and David N. Silverman and Diane E. Cabelli},
  journal={Biochemistry},
  year={2008},
  volume={47 8},
  pages={2350-6}
}
Deinococcus radiodurans (Drad), a bacterium with an extraordinary capacity to tolerate high levels of ionizing radiation, produces only a manganese-containing superoxide dismutase (MnSOD). As MnSOD has been shown to remove superoxide radical with varying efficiency depending upon its cellular origin, a comparison of the Drad MnSOD efficiency with that of both human and Escherichia coli MnSODs was undertaken. Pulse radiolysis studies demonstrate that, under identical ratios of enzyme to… CONTINUE READING

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Kinetic studies of superoxide dismutases: properties of the manganese-containing protein from Thermus thermophilus

  • C. Bull, E. C. Niederhoffer, T. Yoshida, J. A. Fee
  • J. Am. Chem
  • 1991
Highly Influential
4 Excerpts

Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms

  • Dennis, J R., +6 authors S. McSweeney
  • Acta Crystallogr., Sect. F: Struct. Biol. Cryst…
  • 2006
1 Excerpt

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