The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding

Abstract

We have probed the nature of the individual kinetic steps in the folding of the Tetrahymena ribozyme by studying the folding kinetics of mutant ribozymes. After rapid formation of the first structural subdomain, a slow step precedes stable formation of the second subdomain. The two central helices of the second subdomain form in an interdependent manner… (More)
DOI: 10.1038/nsb0596-432

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