The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.

@article{Dietrich2008TheKM,
  title={The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.},
  author={Kristen A Dietrich and Charles Vaughn Sindelar and Paul Duffield Brewer and Kenneth H Downing and Christine R Cremo and Sarah E. Rice},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 26},
  pages={8938-43}
}
Kinesin-1 is a molecular motor protein that transports cargo along microtubules. Inside cells, the vast majority of kinesin-1 is regulated to conserve ATP and to ensure its proper intracellular distribution and coordination with other molecular motors. Regulated kinesin-1 folds in half at a hinge in its coiled-coil stalk. Interactions between coiled-coil regions near the enzymatically active heads at the N terminus and the regulatory tails at the C terminus bring these globular elements in… CONTINUE READING

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