The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes

@article{Song2007TheKA,
  title={The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes},
  author={Jianxun Song and Shahram Salek-Ardakani and Takanori So and Michael Croft},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={64-73}
}
CD28-deficient T cells arrest at the G1–S transition of the cell cycle. Here we show that this is controlled by the kinase aurora B, which exists in a complex with survivin and mammalian target of rapamycin (mTOR). Expression of aurora B in Cd28−/− T cells augmented phosphorylation of mTOR substrates, expression of cyclin A, hyperphosphorylation of retinoblastoma protein and activation of cyclin-dependent kinases 1 and 2 and promoted cell cycle progression. Interleukin 2 enhanced aurora B… CONTINUE READING
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