The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

@article{Delgoffe2011TheKM,
  title={The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2},
  author={Greg M. Delgoffe and Kristen N. Pollizzi and A. Waickman and Emily B. Heikamp and D. Meyers and M. Horton and B. Xiao and P. Worley and J. Powell},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={295-303}
}
The kinase mTOR has emerged as an important regulator of the differentiation of helper T cells. Here we demonstrate that differentiation into the TH1 and TH17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate TH1 and TH17 responses in vitro and in vivo and did not induce classical experimental autoimmune encephalomyelitis (EAE). However, they retained their ability… Expand
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