The kidneys in paroxysmal nocturnal hemoglobinuria.

  title={The kidneys in paroxysmal nocturnal hemoglobinuria.},
  author={David A. Clark and Stephen Andrew Butler and Victor Braren and R C Hartmann and D E Jenkins},
  volume={57 1},
Long-term study of 21 PNH patients revealed an unexpectedly high incidence of functional and anatomic renal abnormalities. Most patients demonstrated varying degrees of hematuria and proteinuria distinct from hemoglobinuria. Evaluation of renal function revealed hyposthenuria, abnormal tubular function, and declining creatinine clearance. Radiologically these patients had enlarged kidneys, cortical infarcts, cortical thinning, and papillary necrosis which were confirmed by autopsy studies… CONTINUE READING
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