The kidney in hyperuricemia and gout.

  title={The kidney in hyperuricemia and gout.},
  author={David B. Mount},
  journal={Current opinion in nephrology and hypertension},
  volume={22 2},
PURPOSE OF REVIEW Gout is a painful inflammatory arthritis associated with hyperuricemia, with a prevalence of almost 10 million in the USA. Reduced renal excretion of urate is the underlying hyperuricemic mechanism in the vast majority of gout patients; most of the genes that affect serum urate level (SUA) encode urate transporters or associated regulatory proteins. Acquired influences can also modulate SUA and renal urate excretion, sometimes precipitating acute gout. Coincidentally, the… CONTINUE READING


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