The kidney as a reservoir for HIV-1 after renal transplantation.

  title={The kidney as a reservoir for HIV-1 after renal transplantation.},
  author={Guillaume Canaud and Nathalie Dejucq-Rainsford and V{\'e}ronique Av{\'e}ttand-F{\'e}no{\"e}l and J P Viard and Dany Anglicheau and Frank Bienaim{\'e} and Mordi Muorah and Louise Galmiche and Olivier Gribouval and L H No{\"e}l and Anne-Pascale Satie and Frank Martinez and R{\'e}becca Sberro-Soussan and Anne Scemla and M K Gubler and G{\'e}rard Friedlander and Corinne Antignac and M O Timsit and Andrea Onetti Muda and Fabiola Terzi and Christine Rouzioux and C. Legendre},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={25 2},
Since the recent publication of data showing favorable outcomes for patients with HIV-1 and ESRD, kidney transplantation has become a therapeutic option in this population. However, reports have documented unexplained reduced allograft survival in these patients. We hypothesized that the unrecognized infection of the transplanted kidney by HIV-1 can compromise long-term allograft function. Using electron microscopy and molecular biology, we examined protocol renal transplant biopsies from 19… CONTINUE READING