INTRODUCTION In the present article, the Authors spread their clinical understanding of genetics and biology of heart failure directly from the bedside investigation of biological systems dynamics through an original diagnostic method with the simple use of the stethoscope, i.e., assessing the splenic arrhythmia (Stagnaro, 1985a) or Morosini’s syndrome (Stagnaro and Caramel, 2012a). Cardiovascular disease (CVD), today’s growing epidemic, is the first cause of death in world-wide. Despite all the current researches, there are still many open questions, such as the well-localized origin of initial endothelial dysfunction and the relationship between genetic causes and environmental risk factors (about 300!) in atherogenesis. For example, not all patients with intense hyper-dyslipidemia are atherosclerotic, and there are individuals suffering of acute myocardial infarction (AMI), in spite of absent dyslipidemia and type 2 DM. On the other hand, one wonders why a large number of patients with hyperinsulinemia-insulin-resistance, hypertension, hyper dyslipidemia live to old age without getting CVD. On the contrary, even without environmental risk factors for atherosclerosis (ATS), in several patients we can see the onset of AMI and stroke. Notoriously, CVD occurs even in individuals without common risk factors, while the CVD may be absent in smoking subjects with impaired blood counts and hypertension.