The key role of mitochondria in Alzheimer's disease.

  title={The key role of mitochondria in Alzheimer's disease.},
  author={Paula I Moreira and Sandra M Cardoso and Maria Santos and Catarina Resende de Oliveira},
  journal={Journal of Alzheimer's disease : JAD},
  volume={9 2},
Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death because they are regulators of both energy metabolism and apoptotic pathways. This review is mainly focused in the discussion of evidence suggesting a clear association between amyloid-beta toxicity, mitochondrial dysfunction, oxidative stress and neuronal damage/death in Alzheimer's disease pathophysiology. The knowledge that mitochondrial dysfunction has a preponderant role in Alzheimer's disease opened… CONTINUE READING


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