The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.


Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor-1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit… (More)
DOI: 10.1016/j.critrevonc.2013.01.005


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