The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

@article{Labrie1997TheKR,
  title={The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology},
  author={F. Labrie and V. Luu‐The and Sheng-Xiang Lin and L. Claude and A. B{\'e}langer},
  journal={Steroids},
  year={1997},
  volume={62},
  pages={148-158}
}
  • F. Labrie, V. Luu‐The, +2 authors A. Bélanger
  • Published 1997
  • Biology
  • Steroids
  • Abstract 17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17β-HSD is performed by at least five 17β-HSD isoenzymes having individual cell-specific expression, substrate specificity, regulation mechanisms, and reductive or oxidative catalytic activity. Both estrogenic and androgenic 17β-HSD activities were found in all 25 rhesus monkey and 15 human peripheral intracrine tissues examined. Type 1 17β-HSD is… CONTINUE READING
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