The key enzyme in galactose metabolism, UDP-galactose-4-epimerase, affects cell-wall integrity and morphology in Candida albicans even in the absence of galactose.

@article{Singh2007TheKE,
  title={The key enzyme in galactose metabolism, UDP-galactose-4-epimerase, affects cell-wall integrity and morphology in Candida albicans even in the absence of galactose.},
  author={Vijender Singh and Somisetty V. Satheesh and Mysore L Raghavendra and P. P. Sadhale},
  journal={Fungal genetics and biology : FG & B},
  year={2007},
  volume={44 6},
  pages={
          563-74
        }
}
The enzyme UDP-galactose-4-epimerase (GAL10) catalyzes a key step in galactose metabolism converting UDP-galactose to UDP-glucose which then can get metabolized through glycolysis and TCA cycle thus allowing the cell to use galactose as a carbon and energy source. As in many fungi, a functional homolog of GAL10 exists in Candida albicans. The domainal organization of the homologs from Saccharomyces cerevisiae and C. albicans show high degree of homology having both mutarotase and an epimerase… CONTINUE READING
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