The ketogenic diet in the treatment of Lennox–Gastaut syndrome

@article{Cross2012TheKD,
  title={The ketogenic diet in the treatment of Lennox–Gastaut syndrome},
  author={J. Helen Cross},
  journal={Developmental Medicine \& Child Neurology},
  year={2012},
  volume={54}
}
  • J. Cross
  • Published 2012
  • Medicine
  • Developmental Medicine & Child Neurology
from their health care team. Researchers have been very effective in identifying possible predictors of cognitive dysfunction. It is now time for our behavioural colleagues to develop effective intervention programs to help parents (and health care professionals) maintain reasonable metabolic control in young children with diabetes and thereby prevent the development of neurocognitive complications. 
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Efficacy of the ketogenic diet in Lennox–Gastaut syndrome: a retrospective review of one institution’s experience and summary of the literature
TLDR
To determine the efficacy of the ketogenic diet for children with Lennox–Gastaut syndrome (LGS) at this institution and in the literature, a large number of children with LGS are treated with the diet. Expand
Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
TLDR
This paper addresses issues such as patient selection, pre‐KD counseling and evaluation, specific dietary therapy selection, implementation, supplementation, follow‐up management, adverse event monitoring, and eventual KD discontinuation. Expand
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial
TLDR
The results from this trial of the ketogenic diet support its use in children with treatment-intractable epilepsy. Expand
Treatment of Lennox-Gastaut syndrome.
TLDR
The optimum treatment for Lennox-Gastaut syndrome remains uncertain and no study to date has shown any one drug to be highly efficacious; lamotrigine, topiramate and felbamate may be helpful as add-on therapy. Expand
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TLDR
This review describes a vulnerability hypothesis and posit that in the very young child diagnosed with diabetes, chronic hyperglycemia initiates a cascade of structural and functional changes within the central nervous system that disrupt normal brain development and those individuals with diabetes who have this cerebral vulnerability will show the greatest degree of neurocognitive impairment. Expand
Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology
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The main issues with regard to the diagnosis and treatment options available are discussed and the importance of a comprehensive approach to the assessment and management of this syndrome is highlighted. Expand
Lennox–Gastaut syndrome in adulthood: Clinical and EEG features
TLDR
In adult LGS patients TS during sleep remain the major seizure type; moreover, a standard waking EEG may be normal; thus, polysomnography represents the most important mean of investigation also in adult L GS patients. Expand
Altered prefrontal glutamateglutaminegamma - aminobutyric acid levels and relation to low cognitive performance and depressive symptoms in type 1 diabetes mellitus
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