The ketogenic diet all grown up—Ketogenic diet therapies for adults

  title={The ketogenic diet all grown up—Ketogenic diet therapies for adults},
  author={Khalil S. Husari and Mackenzie Carpenter Cervenka},
  journal={Epilepsy Research},


This narrative review aims to summarize the available evidence on the possible mechanisms of action, on the efficacy of the ketogenic diet and its variants on the treatment of epilepsy from infants to adults.

Ketogenic Diet Therapy for the Treatment of Post-encephalitic and Autoimmune-Associated Epilepsies

KDT may be a safe and feasible option for the treatment of chronic PE and AE, particularly in those with prior history of SE, and Prospective studies are warranted to explore the efficacy of KDT in management of patients withPE and AE.

Ketogenic dietary therapy in adult status epilepticus: current progress and clinical application

The efficacy and utility of KD in adult SE patients and its application for clinical reference and management are reviewed and highlighted.

Dietary Treatments for Epilepsy

Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels

This review aims to describe some of the possible genes involved in Wnt pathways, their regulation through the KATP channels which are implicated in each one of the diets, and how they can reduce epileptic seizures at the molecular level.

Energy Metabolism and Ketogenic Diets: What about the Skeletal Health? A Narrative Review and a Prospective Vision for Planning Clinical Trials on this Issue

Clinical studies were adequately designed to investigate bone health are scarce and bone health related aspects are not included among the various metabolic pathologies positively influenced by ketogenic diets.

Effects of the Ketogenic Diet on Muscle Hypertrophy in Resistance-Trained Men and Women: A Systematic Review and Meta-Analysis

Ketogenic diets, taking into account the possible side effects, can be an alternative for increasing muscle mass as long as energy surplus is generated; however, their application for eight weeks or more without interruption does not seem to be the best option due to the satiety and lack of adherence generated.

Keto-Sleuths – An Unusual Cause of Loss of Ketosis?

An unusual environmental cause of loss of ketosis is described (contamination with starch-containing drywall dust), illustrating the extent of investigation sometimes necessary to understand the clinical scenario.

Super-refractory status epilepticus and ketogenic diet in intensive care: a series report

A case series of three patients admitted to an intensive care unit due to super-refractory status epilepticus who were managed with a ketogenic diet is reported and a clinical approach to its initiation, transition, and management of clinical intercurrences is proposed.



Lessons learned from recent clinical trials of ketogenic diet therapies in adults.

Clinical studies of KDTs show promise for a variety of clinical indications and should factor in high potential participant attrition rates and utilize consistent and standard reporting of diet type(s), compliance measures, and side-effects to enable the reproducibility and generalizability of study outcomes.

Ketogenic diet for treatment of intractable epilepsy in adults: A meta‐analysis of observational studies

The meta‐analysis indicates that the ketogenic diet for refractory epilepsy in adults is a well‐tolerated treatment and that its side effects are acceptable, which show that the KD is a promising treatment in adult intractable epilepsy.

The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children.

The ketogenic diet should be considered as alternative therapy for children with difficult-to-control seizures and is more effective than many of the new anticonvulsant medications and is well tolerated by children and families when it is effective.

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group

A revised version of this guideline for the management of children on Ketogenic dietary therapies is presented, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation.