The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain

  title={The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain},
  author={Robert William Gear and Christine A. Miaskowski and Newton C. Gordon and Steven M. Paul and Philip H. Heller and Jon D. Levine},

A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain.

  • R. GearN. Gordon J. Levine
  • Biology, Medicine
    The journal of pain : official journal of the American Pain Society
  • 2008

Neuroleptics antagonize nalbuphine antianalgesia.

Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study

The hypothesis that although nalbuphine was found to be an effective and well-tolerated analgesic after major abdominal surgery, females were statistically more responsive than males is supported.

Experimental Pain Models Reveal No Sex Differences in Pentazocine Analgesia in Humans

Findings indicate significant analgesic responses to pentazocine in both men and women across multiple experimental pain assays, and the absence of sex differences contrasts with previous data from the oral surgery model, suggesting that sex differences in opioid analgesia may be specific to certain types of pain.



Gender difference in analgesic response to the kappa-opioid pentazocine

A study of the analgesic interaction between intrathecal morphine and subcutaneous nalbuphine in the rat.

The results indicate a complex analgesic interaction between intrathecal morphine and sc nalbuphine, which reversed opioid-induced respiratory depression and enhanced the effect of morphine in the paw pressure test compared with intr Athecal morphine + sc saline-treated rats.

Comparative Effects and Analgesic Efficacy of the Agonist-Antagonist Opioids

Pentazocine, butorphanol, nalbuphine, and buprenorphine are mixed agonist-antagonist opioids that are effective analgesics, with less abuse potential than the agonists morphine, propoxyphene, and

Nalbuphine. A preliminary review of its pharmacological properties and therapeutic efficacy.

Nalbuphine appears to offer a useful alternative to morphine in patients with moderate to severe pain and appears to produce satisfactory anaesthesia when used as a component of a 'balanced' anaesthesia technique, although a relatively low 'ceiling' effect for reduction of anaesthetic requirements with nal Buphine may limit its usefulness.

A comparison of nalbuphine and meperidine in treatment of postoperative pain

The significantly lower incidence of nausea and vomiting with nalbuphine is a major advantage for a recovery room analgesic and the overall acceptability of the treatment was recorded for 150 patients.

Enhancement of morphine analgesia by the GABAB agonist baclofen

Cellular mechanism for anti-analgesic action of agonists of the κ-opioid receptor

In rats, κ-receptor activation in this brainstem nucleus significantly attenuates local μ-re receptor-mediated analgesia, suggesting a new cellular mechanism for the potentially ubiquitous opposing interaction between μ- and λ-opioid receptors and may help in the design of treatments for pain.