The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain

@article{Gear1999TheKO,
  title={The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain},
  author={Robert William Gear and Christine A. Miaskowski and Newton C. Gordon and Steven M. Paul and Philip H. Heller and Jon D. Levine},
  journal={PAIN},
  year={1999},
  volume={83},
  pages={339-345}
}

A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain.

  • R. GearN. Gordon J. Levine
  • Biology, Medicine
    The journal of pain : official journal of the American Pain Society
  • 2008

Neuroleptics antagonize nalbuphine antianalgesia.

Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study

The hypothesis that although nalbuphine was found to be an effective and well-tolerated analgesic after major abdominal surgery, females were statistically more responsive than males is supported.

Experimental Pain Models Reveal No Sex Differences in Pentazocine Analgesia in Humans

Findings indicate significant analgesic responses to pentazocine in both men and women across multiple experimental pain assays, and the absence of sex differences contrasts with previous data from the oral surgery model, suggesting that sex differences in opioid analgesia may be specific to certain types of pain.
...

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