The kappa-like pre-B receptor: surplus biology or a missing link?

@article{McKeller2006TheKP,
  title={The kappa-like pre-B receptor: surplus biology or a missing link?},
  author={Morgan R. McKeller and Hector Martinez-Valdez},
  journal={Seminars in immunology},
  year={2006},
  volume={18 1},
  pages={40-3}
}
After the demonstration that surrogate JCkappa polypeptides could covalently bind mu heavy chain and upon the characterization of the Vkappa-like component of the kappa-like pre-B cell receptor, it became evident that germline transcription is not sterile. The present review discusses the concept of the alternative usage of kappa-like pre-B cell receptors and classical pre-B cell receptors utilizing the lambda-like surrogate light chain composed of lambda5 and VpreB. We propose that both kappa… CONTINUE READING