The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.

@article{Mattheus2010TheKB,
  title={The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.},
  author={Wesley Mattheus and Joleen Masschelein and Ling-Jie Gao and Piet Herdewijn and Bart Landuyt and G. Volckaert and Rob Lavigne},
  journal={Chemistry & biology},
  year={2010},
  volume={17 10},
  pages={1067-71}
}
BatG is a trans-2-enoyl-ACP reductase, encoded in the kalimantacin/batumin (kal/bat) biosynthesis operon. It is not essential for the production of the kal/bat secondary metabolite. Instead, BatG is an isoform of FabI, conferring full resistance to target bacteria. It also complements FabI in its role in fatty acid biosynthesis. The identification of FabI as the antibacterial target is important to assess clinical potential of the kalimantacin/batumin antibiotics against Staphylococcus aureus. 

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

saFabI, the enoyl reductase from Staphylococcus aureus

  • J. Lin, J. Ma, J. E. Cronan, H. Wang
  • Biochemistry
  • 2010

Similar Papers

Loading similar papers…