The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction.

@article{Hahlbeck2004TheJT,
  title={The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction.},
  author={Edda Hahlbeck and Ioanna Katsiadaki and Ian Mayer and Margaretha Adolfsson-Erici and Jonathan James and Bengt-Erik Bengtsson},
  journal={Aquatic toxicology},
  year={2004},
  volume={70 4},
  pages={311-26}
}
This study investigated the suitability of juvenile three-spined sticklebacks, Gasterosteus aculeatus L., for detecting both androgen- and oestrogen-induced endocrine disruption. The investigated endpoints were kidney hypertrophy and the induction of the protein markers spiggin and vitellogenin. Juveniles were exposed to steroid hormones 17 beta-oestradiol (E2: nominal 0.01, 1.0 and 10 microg/L), 17 alpha-ethinylestradiol (EE2: nominal 0.05 microg/L) and 17 alpha-methyltestosterone (MT: nominal… CONTINUE READING
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