The journey of developing hematopoietic stem cells.

  title={The journey of developing hematopoietic stem cells.},
  author={Hanna K A Mikkola and Stuart H Orkin},
  volume={133 19},
Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that involves multiple anatomical sites. Once HSC precursors have been specified from mesoderm, they have to mature into functional HSCs and undergo self-renewing divisions to generate a pool of HSCs. During this process, developing HSCs migrate through various embryonic niches, which provide signals for their establishment and the conservation of their self-renewal ability. These processes have to be… CONTINUE READING