The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli.

@article{Okada1997TheIG,
  title={The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli.},
  author={Kiyoshi Okada and M Minehira and Xiao Fan Zhu and Katsuhisa Suzuki and Tsuyoshi Nakagawa and Hideyuki Matsuda and Makoto Kawamukai},
  journal={Journal of bacteriology},
  year={1997},
  volume={179 9},
  pages={
          3058-60
        }
}
The Escherichia coli ispB gene encoding octaprenyl diphosphate synthase is responsible for the synthesis of the side chain of isoprenoid quinones. We tried to construct an E. coli ispB-disrupted mutant but could not isolate the chromosomal ispB disrupted mutant unless the ispB gene or its homolog was supplied on a plasmid. The chromosomal ispB disruptants that harbored plasmids carrying the ispB homologs from Haemophilus influenzae and Synechocystis sp. strain PCC6803 produced mainly ubiquinone… CONTINUE READING
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