The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma

@article{Ruminy2011TheIO,
  title={The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma},
  author={Philippe Ruminy and Pascaline Etancelin and Lucile Couronn{\'e} and Françoise Parmentier and Vinciane Rainville and S Mareschal and Elodie Bohers and Celine Burgot and Marie Cornic and Pierre Bertrand and Bernard Lenormand and J M Picquenot and Fabrice Jardin and Herv{\'e} Tilly and Christian Bastard},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={681-688}
}
Gene expression profiling has identified two major molecular subtypes of diffuse large B-cell lymphoma (DLBCL) that are histologically indistinguishable but differ in cure rates. Here, we investigated whether the isotype of the B-cell receptor (BCR) expressed by the tumoral cells correlated with the molecular subtype and survival. Gene expression analysis clustered the 53 patients included in this study into three subgroups, 17 germinal center B-cell-like (GCB) cases, 26 activated B-cell-like… CONTINUE READING