The isolation of thymidine-requiring Haemophilus influenzae from the sputum of chronic bronchitic patients receiving trimethoprim.

@article{Platt1983TheIO,
  title={The isolation of thymidine-requiring Haemophilus influenzae from the sputum of chronic bronchitic patients receiving trimethoprim.},
  author={David J. Platt and Alan J Guthrie and C E Langan},
  journal={The Journal of antimicrobial chemotherapy},
  year={1983},
  volume={11 3},
  pages={
          281-6
        }
}
Two different strains of thymidine-requiring Haemophilus influenzae (thy-) were isolated from the sputum of two patients with chronic obstructive airways disease, during therapy with oral trimethoprim for the treatment of an acute exacerbation of chronic bronchitis. Both patients responded clinically. Since trimethoprim levels in sputum and serum were very low the patients were probably non-compliant. Isolates of H. influenzae prototrophic for thymidine (thy+) were isolated from both patients… CONTINUE READING