The isolation of super-sensitive anti-hapten antibodies from combinatorial antibody libraries derived from sheep.

@article{Charlton2001TheIO,
  title={The isolation of super-sensitive anti-hapten antibodies from combinatorial antibody libraries derived from sheep.},
  author={K. Charlton and W. Harris and A. Porter},
  journal={Biosensors & bioelectronics},
  year={2001},
  volume={16 9-12},
  pages={
          639-46
        }
}
The complexity and expense of producing anti-hapten monoclonals via the traditional hybridoma route and the preferential selection of antibodies that recognise the conjugated form of the hapten, over antibodies that specifically recognise free hapten, are two of the more important problems that have limited the development and application of anti-hapten antibodies. The advent of phage display technology allows the rapid isolation of monoclonal antibody fragments from libraries of different… Expand
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