The isolation and characterization of rubradirin B.

  title={The isolation and characterization of rubradirin B.},
  author={Herman Hoeksema and C. Lewis and Stephen A. Mizsak and J A Shiley and Daniel R. Wait and Howard A. Whaley and Gary E. Zurenko},
  journal={The Journal of antibiotics},
  volume={31 10},
Rubradirin B, C40H33N3O15, was separated from other components of the rubradirin complex by chromatographic and crystallization procedures. The spectrum of antibacterial activity is similar to that of rubradirin, but the antibiotic is less active. 
10 Citations
The chemistry of rubradirin. II. Rubranitrose.
It is reported that acid hydrolysis of rubradirin afforded this fragment which was found to be a nitrosugar which is shown to have structure la, which is stereoisomeric with evernitrose, found in the unrelated antibiotics, everninomicins B and C. Expand
Inhibition of ribosomal and RNA polymerase functions by rubradirin and its aglycone.
  • F. Reusser
  • Biology, Medicine
  • The Journal of antibiotics
  • 1979
The antibiotic rubradirin is structurally related to the ansamycin family of antibiotics and its aglycone acts essentially as an extremely potent inhibitor of RNAP. Expand
Biosynthesis of 3,5-AHBA-derived natural products.
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Rifamycin SV and related ansamycins.
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Naturally-occurring nitro compounds.
This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group. Expand
Chapter 11 Antibiotics
The synthesis and antimicrobial profile of a series of 7-(β-heteroacylamino) cephalosporins have been described and they showed moderate antibacterial activity in vitro and in vivo. Expand
Chapter 3 Pyridine and Piperidine Alkaloids
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The chemistry of the rubradirins. I. The structures of rubransarols A and B.
The antibiotic rubradirin, C48H46N4O20, and the rubransarols are shown to be unique ansamycins which are isomeric at a double bond in the large ring. Expand
Chemical modification of lincomycin: synthesis and bioactivity of selected 2,7-dialkylcarbonate esters.
Serum hydrolysis studies on certain 2,7-diesters of lincomycin established that a high degree of esterase activity is present in the serum of several different rodent species and appeared to be limited to these species. Expand