The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis.

@article{Mole2005TheIP,
  title={The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis.},
  author={Damian J Mole and Mark A Taylor and N. V. Mcferran and Thomas Diamond},
  journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]},
  year={2005},
  volume={5 4-5},
  pages={
          475-85
        }
}
BACKGROUND/AIM During severe acute pancreatitis (AP), the liver may show an exaggerated response to the inflammatory products of gut injury transported in the portal vein. Our aim was to explore liver proinflammatory mediator production after a 'second hit' of portal lipopolysaccharide (LPS) during AP. METHODS Twenty-four rats underwent one of three 'first-hit' scenarios: (1) severe AP induced by intraductal glycodeoxycholic acid injection and intravenous caerulein infusion, (2) sham… CONTINUE READING
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