The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.

@article{Upshaw2005TheIO,
  title={The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.},
  author={Jadee L. Upshaw and Renee A. Schoon and Christopher J. Dick and Daniel D Billadeau and Paul J. Leibson},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={213-8}
}
The two isoforms of phospholipase C (PLC)-gamma couple immune recognition receptors to important calcium- and protein kinase C-dependent cellular functions. It has been assumed that PLC-gamma1 and PLC-gamma2 have redundant functions and that the receptors can use whichever PLC-gamma isoform is preferentially expressed in a cell of a given hemopoietic lineage. In this study, we demonstrate that ITAM-containing immune recognition receptors can use either PLC-gamma1 or PLC-gamma2, whereas the… CONTINUE READING

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